Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA

Group 3 innate lymphoid cells (ILC3s) play critical roles in innate immunity and gut homeostasis. However, how ILC3 homeostasis is regulated remains elusive. Here, we identified a novel circular RNA, circZbtb20, that is highly expressed in ILC3s and required for their maintenance and function. CircZ...

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Bibliografiske detaljer
Udgivet i:Cell Mol Immunol
Main Authors: Liu, Benyu, Liu, Nian, Zhu, Xiaoxiao, Yang, Liuliu, Ye, Buqing, Li, Huimu, Zhu, Pingping, Lu, Tiankun, Tian, Yong, Fan, Zusen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166869/
https://ncbi.nlm.nih.gov/pubmed/33911218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-021-00680-1
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