In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models

BACKGROUND: Dendritic cells (DCs) are a promising therapeutic target in cancer immunotherapy given their ability to prime antigen-specific T cells, and initiate antitumor immune response. A major obstacle for DC-based immunotherapy is the difficulty to obtain a sufficient number of functional DCs. T...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Oba, Takaaki, Makino, Kenichi, Kajihara, Ryutaro, Yokoi, Toshihiro, Araki, Ryoko, Abe, Masumi, Minderman, Hans, Chang, Alfred E, Odunsi, Kunle, Ito, Fumito
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Oncolytic and Local Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166607/
https://ncbi.nlm.nih.gov/pubmed/34049930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002432
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