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Elementary mechanisms of calmodulin regulation of Na(V)1.5 producing divergent arrhythmogenic phenotypes
In cardiomyocytes, Na(V)1.5 channels mediate initiation and fast propagation of action potentials. The Ca(2+)-binding protein calmodulin (CaM) serves as a de facto subunit of Na(V)1.5. Genetic studies and atomic structures suggest that this interaction is pathophysiologically critical, as human muta...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8166197/ https://ncbi.nlm.nih.gov/pubmed/34021086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025085118 |
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