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Bilobal architecture is a requirement for calmodulin signaling to Ca(V)1.3 channels
Calmodulin (CaM) regulation of voltage-gated calcium (Ca(V)) channels is a powerful Ca(2+) feedback mechanism that adjusts Ca(2+) influx, affording rich mechanistic insights into Ca(2+) decoding. CaM possesses a dual-lobed architecture, a salient feature of the myriad Ca(2+)-sensing proteins, where...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5879666/ https://ncbi.nlm.nih.gov/pubmed/29531055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716381115 |
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