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CXCR4/CXCL12-mediated entrapment of axons at the injury site compromises optic nerve regeneration
Regenerative failure in the mammalian optic nerve is generally attributed to axotomy-induced retinal ganglion cell (RGC) death, an insufficient intrinsic regenerative capacity, and an extrinsic inhibitory environment. Here, we show that a chemoattractive CXCL12/CXCR4-dependent mechanism prevents the...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8166183/ https://ncbi.nlm.nih.gov/pubmed/34011605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016409118 |
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