DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions

Regulatory T (Treg) cells that express forkhead box P3 (Foxp3) are pivotal for immune tolerance. Although inflammatory mediators cause Foxp3 instability and Treg cell dysfunction, their regulatory mechanisms remain incompletely understood. Here, we show that the transfer of Treg cells deficient in t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sato, Kazuki, Yamashita-Kanemaru, Yumi, Abe, Fumie, Murata, Rikito, Nakamura-Shinya, Yuho, Kanemaru, Kazumasa, Muratani, Masafumi, Veillette, André, Goto, Motohito, Ito, Mamoru, Shibuya, Akira, Shibuya, Kazuko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166105/
https://ncbi.nlm.nih.gov/pubmed/34011606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021309118
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