Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities

Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive, although they often show signs of prior clonal expansion. Hypothesizing that this may be due to peripheral tolerance, we formulated nanoparticles containing innate immune stimulants...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yin, Qian, Yu, Wong, Grzeskowiak, Caitlin L., Li, Jing, Huang, Huang, Guo, Jing, Chen, Liang, Wang, Feng, Zhao, Fan, von Boehmer, Lotta, Metzner, Thomas J., Leppert, John T., Chien, Yueh-hsiu, Kuo, Calvin J., Davis, Mark M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166076/
https://ncbi.nlm.nih.gov/pubmed/34021082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016168118
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