Nanopore Sequencing Indicates That Tandem Amplification of Chromosome 20q11.21 in Human Pluripotent Stem Cells Is Driven by Break-Induced Replication

Copy number variants (CNVs) are genomic rearrangements implicated in numerous congenital and acquired diseases, including cancer. The appearance of culture-acquired CNVs in human pluripotent stem cells (PSCs) has prompted concerns for their use in regenerative medicine. A particular problem in PSC i...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Halliwell, Jason A., Baker, Duncan, Judge, Kim, Quail, Michael A., Oliver, Karen, Betteridge, Emma, Skelton, Jason, Andrews, Peter W., Barbaric, Ivana
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8165465/
https://ncbi.nlm.nih.gov/pubmed/33757297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2021.0013
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