Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties

Epithelial ovarian cancer (EOC) is a highly heterogeneous disease with a high death rate mainly due to the metastatic spread. The expression of MDM4, a well-known p53-inhibitor, is positively associated with chemotherapy response and overall survival (OS) in EOC. However, the basis of this associati...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Lucà, Rossella, Assenza, Maria Rita, Maiullari, Fabio, Pieroni, Luisa, Maiullari, Silvia, Federici, Giulia, Marini, Federica, Rizzi, Roberto, Urbani, Andrea, Soddu, Silvia, Moretti, Fabiola
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164635/
https://ncbi.nlm.nih.gov/pubmed/34052831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03828-z
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