CtIP suppresses primary microRNA maturation and promotes metastasis of colon cancer cells in a xenograft mouse model

miRNAs are important regulators of eukaryotic gene expression. The post-transcriptional maturation of miRNAs is controlled by the Drosha-DiGeorge syndrome critical region gene 8 (DGCR8) microprocessor. Dysregulation of miRNA biogenesis has been implicated in the pathogenesis of human diseases, inclu...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Ren, Jianping, Wu, Yan, Wang, Ya, Zhao, Yuqin, Li, Youhang, Hao, Shuailin, Lin, Lixiu, Zhang, Shuyuan, Xu, Xingzhi, Wang, Hailong
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164041/
https://ncbi.nlm.nih.gov/pubmed/33901493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100707
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