CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A(2A) receptor (A(2A)R). Using both murine and human chimeric antigen receptor (CAR) T cells, here we show that targeting A(2A...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Giuffrida, Lauren, Sek, Kevin, Henderson, Melissa A., Lai, Junyun, Chen, Amanda X. Y., Meyran, Deborah, Todd, Kirsten L., Petley, Emma V., Mardiana, Sherly, Mølck, Christina, Stewart, Gregory D., Solomon, Benjamin J., Parish, Ian A., Neeson, Paul J., Harrison, Simon J., Kats, Lev M., House, Imran G., Darcy, Phillip K., Beavis, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163771/
https://ncbi.nlm.nih.gov/pubmed/34050151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23331-5
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