CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A(2A) receptor (A(2A)R). Using both murine and human chimeric antigen receptor (CAR) T cells, here we show that targeting A(2A...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Giuffrida, Lauren, Sek, Kevin, Henderson, Melissa A., Lai, Junyun, Chen, Amanda X. Y., Meyran, Deborah, Todd, Kirsten L., Petley, Emma V., Mardiana, Sherly, Mølck, Christina, Stewart, Gregory D., Solomon, Benjamin J., Parish, Ian A., Neeson, Paul J., Harrison, Simon J., Kats, Lev M., House, Imran G., Darcy, Phillip K., Beavis, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163771/
https://ncbi.nlm.nih.gov/pubmed/34050151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23331-5
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