A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes

A convergent synthetic strategy to Cryptococcus neoformans glucuronoxylomannan (GXM) capsular polysaccharide part structures was developed based on di-, tri-, tetra-, penta- and hexasaccharide thioglycoside building blocks. The approach permitted the synthesis of a library of spacer-containing serot...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Chem Sci
Autori principali: Guazzelli, Lorenzo, Crawford, Conor J., Ulc, Rebecca, Bowen, Anthony, McCabe, Orla, Jedlicka, Anne J., Wear, Maggie P., Casadevall, Arturo, Oscarson, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society of Chemistry 2020
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163368/
https://ncbi.nlm.nih.gov/pubmed/34123169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01249a
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