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Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond

Disulfide bridges contribute to the definition and rigidity of polypeptides, but they are inherently unstable in reducing environments and in the presence of isomerases and nucleophiles. Strategies to address these deficiencies, ideally without significantly perturbing the structure of the polypepti...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Zhao, Rui, Shi, Pan, Chen, Junyou, Sun, Shuaishuai, Chen, Jingnan, Cui, Jibin, Wu, Fangming, Fang, Gemin, Tian, Changlin, Shi, Jing, Bierer, Donald, Liu, Lei, Li, Yi-Ming
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society of Chemistry 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163063/
https://ncbi.nlm.nih.gov/pubmed/34094161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc02374d
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