Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights Distinction between External and Internal Diselenide Bridges

Long-acting insulin analogues represent the most prescribed class of therapeutic proteins. An innovative design strategy was recently proposed: diselenide substitution of an external disulfide bridge. This approach exploited the distinctive physicochemical properties of selenocysteine (U). Relative...

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Publicado no:Chemistry
Main Authors: Dhayalan, Balamurugan, Chen, Yen-Shan, Phillips, Nelson B., Swain, Mamuni, Rege, Nischay, Mirsalehi, Ali, Jarosinski, Mark, Ismail-Beigi, Faramarz, Metanis, Norman, Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162893/
https://ncbi.nlm.nih.gov/pubmed/31958351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202000309
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