Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis

BACKGROUND: Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation. Whether they affect outcomes differentially in mechanically ventila...

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Vydáno v:N Engl J Med
Hlavní autoři: Hughes, Christopher G., Mailloux, Patrick T., Devlin, John W., Swan, Joshua T., Sanders, Robert D., Anzueto, Antonio, Jackson, James C., Hoskins, Aimee S., Pun, Brenda T., Orun, Onur M., Raman, Rameela, Stollings, Joanna L., Kiehl, Amy L., Duprey, Matthew S., Bui, Lan N., O’Neal, Hollis R., Snyder, Allison, Gropper, Michael A., Guntupalli, Kalpalatha K., Stashenko, Gregg J., Patel, Mayur B., Brummel, Nathan E., Girard, Timothy D., Dittus, Robert S., Bernard, Gordon R., Ely, E. Wesley, Pandharipande, Pratik P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162695/
https://ncbi.nlm.nih.gov/pubmed/33528922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2024922
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