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Catalytic asymmetric synthesis of quaternary trifluoromethyl α- to ε-amino acid derivatives via umpolung allylation/2-aza-Cope rearrangement

In this study, we developed an efficient Ir-catalyzed cascade umpolung allylation/2-aza-Cope rearrangement of tertiary α-trifluoromethyl α-amino acid derivatives for the preparation of a variety of quaternary α-trifluoromethyl α-amino acids in high yields with excellent enantioselectivities. The ump...

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書誌詳細
出版年:Chem Sci
主要な著者: Sun, Xi-Shang, Wang, Xing-Heng, Tao, Hai-Yan, Wei, Liang, Wang, Chun-Jiang
フォーマット: Artigo
言語:Inglês
出版事項: The Royal Society of Chemistry 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162408/
https://ncbi.nlm.nih.gov/pubmed/34094346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04685j
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