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Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids

Sleep apnoea (SA) increases opioid-induced respiratory depression (OIRD) and lethality. To test the hypothesis that this results from chronic intermittent bouts of hypercapnic hypoxia (CIHH) accompanying SA, we compared OIRD across continuously normoxic control rats and rats exposed to sleep-phase (...

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Veröffentlicht in:J Physiol
Hauptverfasser: Brackley, Allison D., Andrade, Mary Ann, Toney, Glenn M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162062/
https://ncbi.nlm.nih.gov/pubmed/32415789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP280021
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