Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance

A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir, the only provisionally approved treatment to-d...

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Published in:Microorganisms
Main Authors: Mari, Alfredo, Roloff, Tim, Stange, Madlen, Søgaard, Kirstine K., Asllanaj, Erblin, Tauriello, Gerardo, Alexander, Leila Tamara, Schweitzer, Michael, Leuzinger, Karoline, Gensch, Alexander, Martinez, Aurélien E., Bielicki, Julia, Pargger, Hans, Siegemund, Martin, Nickel, Christian H., Bingisser, Roland, Osthoff, Michael, Bassetti, Stefano, Sendi, Parham, Battegay, Manuel, Marzolini, Catia, Seth-Smith, Helena M. B., Schwede, Torsten, Hirsch, Hans H., Egli, Adrian
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160703/
https://ncbi.nlm.nih.gov/pubmed/34069681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms9051094
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