Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance

A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir, the only provisionally approved treatment to-d...

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Bibliografski detalji
Izdano u:Microorganisms
Glavni autori: Mari, Alfredo, Roloff, Tim, Stange, Madlen, Søgaard, Kirstine K., Asllanaj, Erblin, Tauriello, Gerardo, Alexander, Leila Tamara, Schweitzer, Michael, Leuzinger, Karoline, Gensch, Alexander, Martinez, Aurélien E., Bielicki, Julia, Pargger, Hans, Siegemund, Martin, Nickel, Christian H., Bingisser, Roland, Osthoff, Michael, Bassetti, Stefano, Sendi, Parham, Battegay, Manuel, Marzolini, Catia, Seth-Smith, Helena M. B., Schwede, Torsten, Hirsch, Hans H., Egli, Adrian
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160703/
https://ncbi.nlm.nih.gov/pubmed/34069681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms9051094
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