A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy

Immune checkpoint inhibitors, such as monoclonal antibodies targeting programmed death 1 (PD-1) and programmed death ligand-1 (PD-L1), have achieved enormous success in the treatment of several cancers. However, monoclonal antibodies are expensive to produce, have poor tumor penetration, and may ind...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Yuanyuan, Gu, Tingxuan, Tian, Xueli, Li, Wenwen, Zhao, Ran, Yang, Wenqian, Gao, Quanli, Li, Tiepeng, Shim, Jung-Hyun, Zhang, Chengjuan, Liu, Kangdong, Lee, Mee-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160380/
https://ncbi.nlm.nih.gov/pubmed/34054817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.654463
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