Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes

The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues that may increase susceptibility or severity in m...

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Vydáno v:Sci Rep
Hlavní autoři: Baratchian, Mehdi, McManus, Jeffrey M., Berk, Mike P., Nakamura, Fumihiko, Mukhopadhyay, Sanjay, Xu, Weiling, Erzurum, Serpil, Drazba, Judy, Peterson, John, Klein, Eric A., Gaston, Benjamin, Sharifi, Nima
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159988/
https://ncbi.nlm.nih.gov/pubmed/34045511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90491-1
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