Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2

The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues that may increase susceptibility or severity in m...

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Publicado en:bioRxiv
Main Authors: Baratchian, Mehdi, McManus, Jeffrey M., Berk, Mike, Nakamura, Fumihiko, Mukhopadhyay, Sanjay, Xu, Weiling, Erzurum, Serpil, Drazba, Judy, Peterson, John, Klein, Eric A., Gaston, Ben, Sharifi, Nima
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574256/
https://ncbi.nlm.nih.gov/pubmed/33083800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.04.21.051201
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