Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin

Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human melanoma cell lines and may confer resistance against chemotherapeutic agents. One such agent, doxorubicin, was shown to incr...

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Argitaratua izan da:Sci Rep
Egile Nagusiak: Lai, Michele, Amato, Rachele, La Rocca, Veronica, Bilgin, Mesut, Freer, Giulia, Spezia, Piergiorgio, Quaranta, Paola, Piomelli, Daniele, Pistello, Mauro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159975/
https://ncbi.nlm.nih.gov/pubmed/34045496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90219-1
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