Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells

Cutaneous melanoma is often resistant to therapy due to its high plasticity, as well as its ability to metabolise chemotherapeutic drugs. Sphingolipid signalling plays a pivotal role in its progression and metastasis. One of the ways melanoma alters sphingolipid rheostat is via over-expression of ly...

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Pubblicato in:Int J Mol Sci
Autori principali: Lai, Michele, La Rocca, Veronica, Amato, Rachele, Freer, Giulia, Costa, Mario, Spezia, Pietro Giorgio, Quaranta, Paola, Lombardo, Giuseppe, Piomelli, Daniele, Pistello, Mauro
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8004726/
https://ncbi.nlm.nih.gov/pubmed/33806766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22063247
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