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ADAM17 boosts cholesterol efflux and downstream effects of HDL on inflammatory pathways in macrophages
OBJECTIVE: High-density lipoprotein (HDL) can exert both anti-inflammatory and pro-inflammatory effects in macrophages due to its ability to induce cholesterol depletion. Because cholesterol depletion also increases sheddase activity of the membrane protease ADAM17 (ADAM metallopeptidase domain 17)...
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| 發表在: | Arterioscler Thromb Vasc Biol |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8159900/ https://ncbi.nlm.nih.gov/pubmed/33882688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.121.315145 |
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