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ADAM17 boosts cholesterol efflux and downstream effects of HDL on inflammatory pathways in macrophages

OBJECTIVE: High-density lipoprotein (HDL) can exert both anti-inflammatory and pro-inflammatory effects in macrophages due to its ability to induce cholesterol depletion. Because cholesterol depletion also increases sheddase activity of the membrane protease ADAM17 (ADAM metallopeptidase domain 17)...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Kothari, Vishal, Tang, Jingjing, He, Yi, Kramer, Farah, Kanter, Jenny E., Bornfeldt, Karin E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159900/
https://ncbi.nlm.nih.gov/pubmed/33882688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.121.315145
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