Altered Responsiveness to TGF-β and BMP and Increased CD45+ Cell Presence in Mitral Valves are Unique Features of Ischemic Mitral Regurgitation

OBJECTIVE: Ischemic mitral regurgitation (IMR) often develops after an ischemic event, which results in distortion of the valvulo-ventricular complex and incomplete mitral valve (MV) leaflet coaptation. After left ventricle (LV) ischemic events, only some patients develop IMR. The susceptibility of...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Castillero, Estibaliz, Howsmon, Daniel P., Rego, Bruno V., Keeney, Samuel, Driesbaugh, Kathryn H., Kawashima, Takayuki, Xue, Yingfei, Camillo, Chiara, George, Isaac, Gorman, Robert C., Gorman, Joseph H., Sacks, Michael S., Levy, Robert J., Ferrari, Giovanni
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159877/
https://ncbi.nlm.nih.gov/pubmed/33827255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.121.316111
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