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Calcineurin inhibitors target Lck activation in graft-versus-host disease
Calcineurin inhibitors (CNIs) such as cyclosporin A and FK506 are widely administered immunosuppressive drugs. Calcineurin relieves inhibitory phosphorylation from nuclear factor of activated T cells (NFAT) transcription factors downstream of T cell receptor engagement, resulting in their nuclear tr...
Shranjeno v:
| izdano v: | J Clin Invest |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8159697/ https://ncbi.nlm.nih.gov/pubmed/34060488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI149934 |
| Oznake: |
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