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Histone deficiency and accelerated replication stress in T cell aging

With increasing age, individuals are more vulnerable to viral infections such as with influenza or the SARS-CoV-2 virus. One age-associated defect in human T cells is the reduced expression of miR-181a. miR-181ab1 deficiency in peripheral murine T cells causes delayed viral clearance after infection...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Kim, Chulwoo, Jin, Jun, Ye, Zhongde, Jadhav, Rohit R., Gustafson, Claire E., Hu, Bin, Cao, Wenqiang, Tian, Lu, Weyand, Cornelia M., Goronzy, Jörg J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159689/
https://ncbi.nlm.nih.gov/pubmed/34060486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143632
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