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Precipitation-free high-affinity multivalent binding by inline lectin ligands

Multivalent ligand–protein interactions are a key concept in biology mediating, for example, signalling and adhesion. Multivalent ligands often have tremendously increased binding affinities. However, they also can cause crosslinking of receptor molecules leading to precipitation of ligand–receptor...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Rohse, Philipp, Weickert, Sabrina, Drescher, Malte, Wittmann, Valentin
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159369/
https://ncbi.nlm.nih.gov/pubmed/34122979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01744b
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