AP-3–dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells

Lamellar bodies (LBs) are lysosome-related organelles (LROs) of surfactant-producing alveolar type 2 (AT2) cells of the distal lung epithelium. Trafficking pathways to LBs have been understudied but are likely critical to AT2 cell homeostasis given associations between genetic defects of endosome to...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kook, Seunghyi, Wang, Ping, Meng, Shufang, Jetter, Christopher S., Sucre, Jennifer M. S., Benjamin, John T., Gokey, Jason J., Hanby, Hayley A., Jaume, Alexa, Goetzl, Laura, Marks, Michael S., Guttentag, Susan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157957/
https://ncbi.nlm.nih.gov/pubmed/33990468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025208118
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