Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis

Pulmonary fibrosis is a relentlessly progressive and often fatal disease with a paucity of available therapies. Genetic evidence implicates disordered epithelial repair, which is normally achieved by the differentiation of small cuboidal alveolar type 2 (AT2) cells into large, flattened alveolar typ...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Watanabe, Satoshi, Markov, Nikolay S., Lu, Ziyan, Piseaux Aillon, Raul, Soberanes, Saul, Runyan, Constance E., Ren, Ziyou, Grant, Rogan A., Maciel, Mariana, Abdala-Valencia, Hiam, Politanska, Yuliya, Nam, Kiwon, Sichizya, Lango, Kihshen, Hermon G., Joshi, Nikita, McQuattie-Pimentel, Alexandra C., Gruner, Katherine A., Jain, Manu, Sznajder, Jacob I., Morimoto, Richard I., Reyfman, Paul A., Gottardi, Cara J., Budinger, G. R. Scott, Misharin, Alexander V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157939/
https://ncbi.nlm.nih.gov/pubmed/33972447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101100118
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