A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Ontologically distinct populations of macrophages differentially contribute to organ fibrosis through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing and single-molecule fluorescence in situ hybridisation to a spatially restricted model of asbestos-induced pulmonary fibros...

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Detalhes bibliográficos
Publicado no:Eur Respir J
Main Authors: Joshi, Nikita, Watanabe, Satoshi, Verma, Rohan, Jablonski, Renea P., Chen, Ching-I, Cheresh, Paul, Markov, Nikolay S., Reyfman, Paul A., McQuattie-Pimentel, Alexandra C., Sichizya, Lango, Lu, Ziyan, Piseaux-Aillon, Raul, Kirchenbuechler, David, Flozak, Annette S., Gottardi, Cara J., Cuda, Carla M., Perlman, Harris, Jain, Manu, Kamp, David W., Budinger, G.R. Scott, Misharin, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: European Respiratory Society 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962769/
https://ncbi.nlm.nih.gov/pubmed/31601718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.00646-2019
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