EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling

BACKGROUND: Somatic mutations are involved in hepatocellular carcinoma (HCC) progression, but the genetic mechanism associated to hepatocarcinogenesis remains poorly understood. We report that Eyes absent homolog 2 (EYA2) suppresses the HCC progression, while EYA2(A510E) mutation identified by exome...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Liu, Ze-Kun, Li, Can, Zhang, Ren-Yu, Wei, Ding, Shang, Yu-Kui, Yong, Yu-Le, Kong, Ling-Min, Zheng, Nai-Shan, Liu, Ke, Lu, Meng, Liu, Man, Hu, Cai-Xia, Yang, Xiao-Zhen, Chen, Zhi-Nan, Bian, Huijie
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157759/
https://ncbi.nlm.nih.gov/pubmed/34044846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-021-01377-9
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