Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans

To determine how to set optimal oral L-serine (serine) dose levels for a clinical trial, existing literature was surveyed. Data sufficient to set the dose was inadequate, and so an (n = 10) phase I-A calibration trial was performed, administering serine with and without other oral agents. We analyze...

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Udgivet i:Front Pharmacol
Main Authors: Bosley, J. R., Björnson, Elias, Zhang, Cheng, Turkez, Hasan, Nielsen, Jens, Uhlen, Mathias, Borén, Jan, Mardinoglu, Adil
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156419/
https://ncbi.nlm.nih.gov/pubmed/34054524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.643179
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