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Design and Catalyzed Activation of Mycophenolic Acid Prodrugs
[Image: see text] Mycophenolic acid (MPA) and its morpholino ester prodrug mycophenolate mofetil (MMF) are widely used in solid organ transplantation. These drugs prevent rejection due to their potent inhibition of inosine-5′-monophosphate dehydrogenase (IMPDH), an enzyme vital for lymphocyte prolif...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2021
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8155237/ https://ncbi.nlm.nih.gov/pubmed/34055230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00079 |
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