Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling

Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but the mechanisms underlying its effect are not well established. We investigated if the antidepressant-like effect induced by guanosine in the tail suspension test (TST) in mice involves the modulation of α-ami...

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Pubblicato in:Purinergic Signal
Autori principali: Rosa, Priscila B., Bettio, Luis E. B., Neis, Vivian B., Moretti, Morgana, Kaufmann, Fernanda N., Tavares, Mauren K., Werle, Isabel, Dalsenter, Yasmim, Platt, Nicolle, Rosado, Axel F., Fraga, Daiane B., Heinrich, Isabella A., Freitas, Andiara E., Leal, Rodrigo B., Rodrigues, Ana Lúcia S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2021
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155134/
https://ncbi.nlm.nih.gov/pubmed/33712981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-021-09779-6
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