Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling

Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but the mechanisms underlying its effect are not well established. We investigated if the antidepressant-like effect induced by guanosine in the tail suspension test (TST) in mice involves the modulation of α-ami...

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Vydáno v:Purinergic Signal
Hlavní autoři: Rosa, Priscila B., Bettio, Luis E. B., Neis, Vivian B., Moretti, Morgana, Kaufmann, Fernanda N., Tavares, Mauren K., Werle, Isabel, Dalsenter, Yasmim, Platt, Nicolle, Rosado, Axel F., Fraga, Daiane B., Heinrich, Isabella A., Freitas, Andiara E., Leal, Rodrigo B., Rodrigues, Ana Lúcia S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155134/
https://ncbi.nlm.nih.gov/pubmed/33712981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-021-09779-6
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