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Increased toxicity and retention of Perflourooctane Sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a High-Fat Diet (HFD)

PFOS is a persistent, fluorosurfactant used in multiple products. Murine Cyp2b’s are induced by PFOS and high-fat diets (HFD) and therefore we hypothesized that human CYP2B6 may alleviate PFOS-induced steatosis. Cyp2b-null and hCYP2B6-Tg mice were treated with 0, 1, or 10mg/kg/day PFOS by oral gavag...

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Detalhes bibliográficos
Publicado no:Food Chem Toxicol
Main Authors: Hamilton, Matthew C., Heintz, Melissa M., Pfohl, Marisa, Marques, Emily, Ford, Lucie, Slitt, Angela L., Baldwin, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154739/
https://ncbi.nlm.nih.gov/pubmed/33838175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2021.112175
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