Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice

Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kumar, Ramiya, Mota, Linda C., Litoff, Elizabeth J., Rooney, John P., Boswell, W. Tyler, Courter, Elliott, Henderson, Charles M., Hernandez, Juan P., Corton, J. Christopher, Moore, David D., Baldwin, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370058/
https://ncbi.nlm.nih.gov/pubmed/28350814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174355
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