Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice

Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kumar, Ramiya, Mota, Linda C., Litoff, Elizabeth J., Rooney, John P., Boswell, W. Tyler, Courter, Elliott, Henderson, Charles M., Hernandez, Juan P., Corton, J. Christopher, Moore, David D., Baldwin, William S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370058/
https://ncbi.nlm.nih.gov/pubmed/28350814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174355
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