ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the emergence of molecular resistance. Trastuzumab’s target epitope is localized within the extracellular domain of the oncogenic ce...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Duarte, Henrique O., Rodrigues, Joana G., Gomes, Catarina, Hensbergen, Paul J., Ederveen, Agnes L. Hipgrave, de Ru, Arnoud H., Mereiter, Stefan, Polónia, António, Fernandes, Elisabete, Ferreira, José A., van Veelen, Peter A., Santos, Lúcio L., Wuhrer, Manfred, Gomes, Joana, Reis, Celso A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154592/
https://ncbi.nlm.nih.gov/pubmed/33947960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01801-w
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker