ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the emergence of molecular resistance. Trastuzumab’s target epitope is localized within the extracellular domain of the oncogenic ce...

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發表在:Oncogene
Main Authors: Duarte, Henrique O., Rodrigues, Joana G., Gomes, Catarina, Hensbergen, Paul J., Ederveen, Agnes L. Hipgrave, de Ru, Arnoud H., Mereiter, Stefan, Polónia, António, Fernandes, Elisabete, Ferreira, José A., van Veelen, Peter A., Santos, Lúcio L., Wuhrer, Manfred, Gomes, Joana, Reis, Celso A.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154592/
https://ncbi.nlm.nih.gov/pubmed/33947960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01801-w
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