Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A(2A) Receptor

[Image: see text] In this study, we determined the crystal structure of an engineered human adenosine A(2A) receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belon...

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Vydáno v:J Med Chem
Hlavní autoři: Amelia, Tasia, van Veldhoven, Jacobus P. D., Falsini, Matteo, Liu, Rongfang, Heitman, Laura H., van Westen, Gerard J. P., Segala, Elena, Verdon, Grégory, Cheng, Robert K. Y., Cooke, Robert M., van der Es, Daan, IJzerman, Adriaan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2021
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154574/
https://ncbi.nlm.nih.gov/pubmed/33764785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01856
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