Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors

[Image: see text] Cancer cells rely on the enzyme telomerase (EC 2.7.7.49) to promote cellular immortality. Telomerase inhibitors (i.e., azidothymidine) can represent promising antitumor agents, although showing high toxicity when administered alone. Better outcomes were observed within a multipharm...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Berrino, Emanuela, Angeli, Andrea, Zhdanov, Dmitry D., Kiryukhina, Anna P., Milaneschi, Andrea, De Luca, Alessandro, Bozdag, Murat, Carradori, Simone, Selleri, Silvia, Bartolucci, Gianluca, Peat, Thomas S., Ferraroni, Marta, Supuran, Claudiu T., Carta, Fabrizio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2020
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154556/
https://ncbi.nlm.nih.gov/pubmed/32463228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00636
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller