Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors

[Image: see text] Cancer cells rely on the enzyme telomerase (EC 2.7.7.49) to promote cellular immortality. Telomerase inhibitors (i.e., azidothymidine) can represent promising antitumor agents, although showing high toxicity when administered alone. Better outcomes were observed within a multipharm...

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Publicat a:J Med Chem
Autors principals: Berrino, Emanuela, Angeli, Andrea, Zhdanov, Dmitry D., Kiryukhina, Anna P., Milaneschi, Andrea, De Luca, Alessandro, Bozdag, Murat, Carradori, Simone, Selleri, Silvia, Bartolucci, Gianluca, Peat, Thomas S., Ferraroni, Marta, Supuran, Claudiu T., Carta, Fabrizio
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154556/
https://ncbi.nlm.nih.gov/pubmed/32463228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00636
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