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Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target
[Image: see text] Finasteride, a 5-alpha reductase (5α-R) inhibitor, is a widely used drug for treating androgen-dependent conditions. However, its use is associated with sexual, psychological, and physical complaints, suggesting that other mechanisms, in addition to 5α-R inhibition, may be involved...
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| Veröffentlicht in: | J Med Chem |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2021
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8154553/ https://ncbi.nlm.nih.gov/pubmed/33843213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02039 |
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