Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with selective inhibition of mitochondrial Complex III an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Le Vasseur, Maxence, Friedman, Jonathan, Jost, Marco, Xu, Jiawei, Yamada, Justin, Kampmann, Martin, Horlbeck, Max A, Salemi, Michelle R, Phinney, Brett S, Weissman, Jonathan S, Nunnari, Jodi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2021
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154037/
https://ncbi.nlm.nih.gov/pubmed/34034859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67624
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