In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

Proteasome-catalyzed peptide splicing (PCPS) of cancer-driving antigens could generate attractive neoepitopes to be targeted by T cell receptor (TCR)-based adoptive T cell therapy. Based on a spliced peptide prediction algorithm, TCRs were generated against putative KRAS(G12V)- and RAC2(P29L)-derive...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Willimsky, Gerald, Beier, Christin, Immisch, Lena, Papafotiou, George, Scheuplein, Vivian, Goede, Andrean, Holzhütter, Hermann-Georg, Blankenstein, Thomas, Kloetzel, Peter M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154032/
https://ncbi.nlm.nih.gov/pubmed/33875134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62019
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados